Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA3 | P07451 | 3/20 | 0.50 |
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | CA6 | P23280 | 3/20 | 0.50 |
| ▸ | CA5A | P35218 | 3/20 | 0.50 |
| ▸ | CA7 | P43166 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL2925808 | 0.96 | DNM1 (0.57) | NFKB1DNM1CA12CA1CA2 | |
| Piperazine SCHEMBL22494138 | 0.96 | DNM1 (0.57) | NFKB1DNM1CA12CA1CA2 | |
| Piperazine SCHEMBL13281519 | 0.85 | DNM1 (0.63) | NFKB1DNM1CA12CA1CA2 | |
| Piperazine SCHEMBL5946683 | 0.84 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL14739784 | 0.84 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL2882663 | 0.84 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL28952742 | 0.83 | ALDH1A1 (0.56) | NFKB1DNM1CA12CA1CA2 | |
| Piperazine SCHEMBL27286374 | 0.83 | DNM1 (0.68) | DNM1CA12CA1CA2CA3 | |
| Piperidine SCHEMBL28041935 | 0.81 | ALDH1A1 (0.53) | NFKB1DNM1CA12CA1CA2 | |
| Piperazine SCHEMBL27476631 | 0.81 | DNM1 (0.50) | NFKB1DNM1TSHRLMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190318855-A1 | SINTERABLE MAGNETIC POWDER COMPOSITION AND THREE-DIMENSIONAL OBJECT MANUFACTURED BY SINTERING SUCH A COMPOSITION | ARKEMA FRANCE (FR) | 2019-10-17 | — | — | US | disclosed |
| US-5244765-A | Toner for developing latent electrostatic images | RICOH COMPANY, LTD. (JP) | 1993-09-14 | — | — | US | disclosed |