Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27797296 | 1.00 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL986910 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL986672 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL986674 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL986909 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNATSHRMAPT | |
| SCHEMBL30594200 | 0.74 | ALDH1A1 (0.31) | ALDH1A1 | |
| Citric Acid SCHEMBL2293604 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Ammonia Solution, Strong SCHEMBL28256968 | 0.72 | ALDH1A1 (0.30) | ALDH1A1 | |
| Citric Acid SCHEMBL7204241 | 0.72 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNATSHRMAPT | |
| Citric Acid SCHEMBL7204691 | 0.72 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113476353-B | Whitening essence suitable for long-term storage and preparation method thereof | 广州天然国度生物科技有限公司 | 2023-04-28 | — | — | CN | claimed |
| CN-118215459-A | Cosmetic composition comprising a mixture of isatin and an oxidizing agent | 娇韵诗实验室 | 2024-06-18 | — | — | CN | disclosed |
| CN-113476353-B | Whitening essence suitable for long-term storage and preparation method thereof | 广州天然国度生物科技有限公司 | 2023-04-28 | — | — | CN | disclosed |