Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL759304 | 0.82 | — | — | |
| SCHEMBL3442900 | 0.78 | GAA (0.33) | ALDH1A1KDM4E | |
| Citric Acid SCHEMBL535786 | 0.76 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL27797296 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL986854 | 0.70 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL985329 | 0.70 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL986838 | 0.70 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL45492 | 0.68 | ALDH1A1 (0.94) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL3454616 | 0.66 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL5874339 | 0.66 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250107987-A1 | NAIL POLISH COMPOSITION CONTAINING PIPERIDINOL COMPOUND | L'OREAL (FR) | 2025-04-03 | — | — | US | claimed |
| CN-118319820-A | Composition with whitening and skin brightening effects and preparation method thereof | 广州旭妆生物科技有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-115137657-B | Composition for stabilizing color of cosmetic gardenia pigment and application thereof | 上海百雀羚生物科技有限公司 | 2024-02-23 | — | — | CN | claimed |
| CN-116251031-A | Stabilized ergothioneine preparation and preparation method thereof | 浙江睿颜新材料科技有限公司 | 2023-06-13 | — | — | CN | claimed |
| US-20250375368-A1 | COSMETIC COMPOSITION INCLUDING A SILOXANE-TREATED COLORANT | L'OREAL (FR) | 2025-12-11 | — | — | US | disclosed |
| US-20250375372-A1 | COSMETIC COMPOSITION INCLUDING AN ALOE-TREATED COLORANT | L'OREAL (FR) | 2025-12-11 | — | — | US | disclosed |
| WO-2025137031-A1 | COMPOSITIONS CONTAINING BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE AND ANTIOXIDANT SYSTEM | L'OREAL (FR) | 2025-06-26 | — | — | WO | disclosed |
| WO-2025137034-A1 | COLOR SKIN COMPOSITIONS CONTAINING BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE AND COLORING AGENT | L'OREAL (FR) | 2025-06-26 | — | — | WO | disclosed |
| WO-2025137032-A1 | COMPOSITIONS CONTAINING BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE AND ACTIVE AGENT | L'OREAL (FR) | 2025-06-26 | — | — | WO | disclosed |
| US-20250195373-A1 | COMPOSITIONS CONTAINING BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE AND OCTINOXATE | L'OREAL (FR) | 2025-06-19 | — | — | US | disclosed |
| US-20250195377-A1 | COMPOSITIONS CONTAINING BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE AND ANTIOXIDANT SYSTEM | L'OREAL (FR) | 2025-06-19 | — | — | US | disclosed |
| US-20250195374-A1 | COMPOSITIONS CONTAINING BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE AND AVOBENZONE | L'ORÉAL (FR) | 2025-06-19 | — | — | US | disclosed |
| CN-115137657-A | Composition for stabilizing color of cosmetic gardenia pigment and application thereof | 上海百雀羚生物科技有限公司 | 2022-10-04 | — | — | CN | disclosed |
| US-10760334-B2 | Electrochromic device structures | POLYCEED INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-20190145161-A1 | ELECTROCHROMIC DEVICE STRUCTURES | POLYCEED INC. (US) | 2019-05-16 | — | — | US | disclosed |
| WO-2019036591-A1 | STABILIZED COLOR DEPOSITING SHAMPOO | Celeb LLC (US) | 2019-02-21 | — | — | WO | disclosed |
| US-8454940-B2 | Mixtures comprising benzotriazoles and merocyanines | BASF SE (DE) | 2013-06-04 | — | — | US | disclosed |
| EP-1945418-B1 | MOLDED SHAVING AID COMPOSITIONS, COMPONENTS AND METHODE OF MANUFACTURE | GILLETTE CO (US) | 2012-07-04 | — | — | EP | disclosed |
| US-20110200540-A1 | MIXTURES COMPRISING BENZOTRIAZOLES AND MEROCYANINES | BASF SE (DE) | 2011-08-18 | — | — | US | disclosed |
| WO-2009059064-A1 | A LONG-ACTING, WATERPROOF OR WATER-RESISTANT, TOPICAL SUN PROTECTION AGENT WITH ACTIVITY UP TO WEEKS | SPHJK, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250375368-A1 | COSMETIC COMPOSITION INCLUDING A SILOXANE-TREATED COLORANT | CUTA, PLIN1, PLOD2 | ALDH1A1 337/4885KDM4E 827/4885LMNA 355/4885 |
| US-20110200540-A1 | MIXTURES COMPRISING BENZOTRIAZOLES AND MEROCYANINES | CRYZ, CRY1, ARNT | ALDH1A1 691/4885KDM4E 1511/4885LMNA 2255/4885 |
| US-20250375372-A1 | COSMETIC COMPOSITION INCLUDING AN ALOE-TREATED COLORANT | ALOX15B, ALOX12, ALOX15 | ALDH1A1 87/4885KDM4E 1708/4885LMNA 2193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.