Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL11405896 | 0.92 | HSPD1 (0.48) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL28027037 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL27042357 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL875432 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL27642067 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL10687560 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL30150820 | 0.86 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL3816409 | 0.86 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL29563289 | 0.86 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL28589360 | 0.86 | FFAR1 (0.61) | HSPD1BLMHSPE1ALDH1A1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118382417-A | Stable compositions comprising retinoids and ascorbic acid compounds | 莱雅公司 | 2024-07-23 | — | — | CN | disclosed |
| CN-114786782-B | Stable composition comprising cinnamic acid derivatives in combination with specific ingredients | 莱雅公司 | 2024-06-25 | — | — | CN | disclosed |