Sugi Predict

Sugi Predict / Compounds / SCHEMBL2926632

SCHEMBL2926632

SCHEMBL2926632

O/N=C/c1ccc(Cl)cc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 3/20 0.47
▸ TSHR P16473 2/20 0.47
▸ KDM4E B2RXH2 3/20 0.44
▸ MAPT P10636 5/20 0.43
▸ GRIN2D O15399 4/20 0.43
▸ GRIN3B O60391 4/20 0.43
▸ GRIN1 Q05586 4/20 0.43
▸ GRIN2A Q12879 4/20 0.43
▸ GRIN2B Q13224 4/20 0.43
▸ GRIN2C Q14957 4/20 0.43
▸ GRIN3A Q8TCU5 4/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ HTT P42858 3/20 0.41
▸ KMT2A Q03164 4/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ MEN1 O00255 2/20 0.38
▸ CYP1A2 P05177 2/20 0.38
▸ CYP3A4 P08684 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4163624 1.00 HPGD (0.47) HPGDTSHRKDM4EMAPTGRIN2D
SCHEMBL2926635 1.00 HPGD (0.47) HPGDTSHRKDM4EMAPTGRIN2D
Hydrochloric Acid SCHEMBL28411174 0.98 HPGD (0.46) HPGDTSHRKDM4EMAPTGRIN2D
SCHEMBL5676565 0.86 HPGD (0.53) HPGDTSHRKDM4EMAPTGRIN2D
SCHEMBL2446282 0.86 HPGD (0.53) HPGDTSHRKDM4EMAPTGRIN2D
SCHEMBL2446279 0.86 HPGD (0.53) HPGDTSHRKDM4EMAPTGRIN2D
SCHEMBL23564759 0.80 GRIN2D (0.40) MAPTGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL1614008 0.80 GRIN2D (0.40) HPGDTSHRKDM4EMAPTGRIN2D
SCHEMBL29756954 0.79 MAPT (0.59) HPGDTSHRKDM4EMAPTGRIN2D
SCHEMBL2904660 0.79 MAPT (0.59) HPGDTSHRKDM4EMAPTGRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12281108-B2 Pyrrolidinone derivatives as formyl peptide 2 receptor agonists BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-22 — — US disclosed
CN-113166134-B Pyrrolidone derivatives as formyl peptide 2 receptor agonists 百时美施贵宝公司 2024-06-14 — — CN disclosed
EP-3887366-B1 PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2023-09-27 — — EP disclosed
EP-3887366-B1 PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2023-09-27 — — EP disclosed
US-20220002281-A1 PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2022-01-06 — — US disclosed
US-20220002281-A1 PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2022-01-06 — — US disclosed
EP-3887366-A1 PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS Bristol-Myers Squibb Company (US) 2021-10-06 — — EP disclosed
CN-113166134-A Pyrrolidone derivatives as formyl peptide 2 receptor agonists 百时美施贵宝公司 2021-07-23 — — CN disclosed
WO-2020157710-A1 4-SUBSTITUTED ISOXAZOLE/ISOXAZOLINE (HETERO) ARYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2020-08-06 — — WO disclosed
WO-2020112583-A1 PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2020-06-04 — — WO disclosed
CN-106336383-B A kind of trinitrogenazole alcohol analog derivative and its preparation method and application 中国人民解放军第二军医大学 2019-05-14 — — CN disclosed
US-20180134696-A1 Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors FORUM PHARMACEUTICALS, INC. 2018-05-17 — — US disclosed
US-20170044155-A1 Geminal Substituted Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors AXOVANT SCIENCES GMBH (CH) 2017-02-16 — — US disclosed
CN-106336383-A Triazole alcohol derivative and preparation method and application thereof 中国人民解放军第二军医大学 2017-01-18 — — CN disclosed
EP-2767536-B1 Isoxazolo-pyridine derivatives HOFFMANN LA ROCHE (CH) 2015-09-02 — — EP disclosed
EP-2227467-B1 ISOXAZOLO-PYRIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2014-12-31 — — EP disclosed
WO-2014160649-A1 HYDROXAMIC ACID DERIVATIVES AS LPXC INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS NOVARTIS AG (CH) 2014-10-02 — — WO disclosed
EP-2767536-A1 ISOXAZOLO-PYRIDINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2014-08-20 — — EP disclosed
EP-2227467-A1 ISOXAZOLO-PYRIDINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2010-09-15 — — EP disclosed
WO-2009071476-A1 ISOXAZOLO-PYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-06-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170044155-A1 Geminal Substituted Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors CHRNA7, CHRNA5, CHRNA6 HPGD 2804/4885TSHR 1585/4885KDM4E 3493/4885
US-12281108-B2 Pyrrolidinone derivatives as formyl peptide 2 receptor agonists FPR1, FPR2, FPR3 HPGD 612/4885TSHR 747/4885KDM4E 4473/4885
US-20220002281-A1 PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS FPR1, FPR2, FPR3 HPGD 612/4885TSHR 747/4885KDM4E 4473/4885
US-20180134696-A1 Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors CHRNA7, CHRNA5, CHRNA2 HPGD 1289/4885TSHR 808/4885KDM4E 3741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.