Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927049 | 0.86 | HPGD (0.67) | HTTHSD17B10KDM4ETSHRMAPT | |
| SCHEMBL6394883 | 0.84 | HPGD (0.63) | HTTHSD17B10KDM4ETSHRMAPT | |
| SCHEMBL981752 | 0.84 | HTT (0.74) | HTTHSD17B10KDM4ETSHRMAPT | |
| SCHEMBL1206476 | 0.79 | HDAC3 (0.48) | KDM4EP2RY12MEN1KMT2A | |
| SCHEMBL2902911 | 0.78 | TDP1 (0.45) | HTTHSD17B10KDM4ETSHRMAPT | |
| SCHEMBL16785589 | 0.77 | ADRB1 (0.47) | HSD17B10KDM4ELMNACYP3A4NPSR1 | |
| SCHEMBL981610 | 0.76 | P2RY12 (0.56) | HTTHSD17B10KDM4ETSHRMAPT | |
| SCHEMBL2909203 | 0.75 | ALDH1A1 (0.54) | HTTHSD17B10KDM4ETSHRMAPT | |
| SCHEMBL19862430 | 0.75 | CASP1 (0.43) | HSD17B10KDM4ELMNACYP3A4NPSR1 | |
| SCHEMBL29521457 | 0.74 | P2RY12 (0.59) | TSHRMAPTHPGDLMNAP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |