Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 16/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.47 |
| ▸ | HPGD | P15428 | 10/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838676 | 0.91 | KDM4E (0.46) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL5008054 | 0.83 | KDM4E (0.47) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL5007922 | 0.82 | L3MBTL1 (0.59) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL2926629 | 0.82 | KDM4E (0.42) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL4998210 | 0.81 | L3MBTL1 (0.55) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL5981594 | 0.80 | MAPT (0.58) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL2929583 | 0.77 | HSD17B10 (0.42) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL7834300 | 0.75 | POLB (0.43) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL4998178 | 0.74 | RXFP1 (0.67) | ALDH1A1TP53RXFP1MEN1KMT2A | |
| SCHEMBL2928566 | 0.72 | HDAC3 (0.49) | KDM4EHSD17B10ALDH1A1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6528650-B2 | Mixture containing coupler | L'OREAL S.A. (FR) | 2003-03-04 | — | — | US | claimed |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2003-01-30 | — | — | US | claimed |
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2002-03-21 | — | — | US | claimed |
| US-6306181-B1 | FOR DYEING HUMAN HAIR | L'OREAL (FR) | 2001-10-23 | — | — | US | claimed |
| EP-0989128-B1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | OREAL (FR) | 2001-03-21 | — | — | EP | claimed |
| EP-0989128-A1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | L'OREAL (FR) | 2000-03-29 | — | — | EP | claimed |
| EP-1728500-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | OREAL (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1728500-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | L'OREAL (FR) | 2006-12-06 | — | — | EP | disclosed |
| US-6528650-B2 | Mixture containing coupler | L'OREAL S.A. (FR) | 2003-03-04 | — | — | US | disclosed |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2003-01-30 | — | — | US | disclosed |
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2002-03-21 | — | — | US | disclosed |
| US-6306181-B1 | FOR DYEING HUMAN HAIR | L'OREAL (FR) | 2001-10-23 | — | — | US | disclosed |
| EP-0989128-B1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | OREAL (FR) | 2001-03-21 | — | — | EP | disclosed |
| EP-0989128-A1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | L'OREAL (FR) | 2000-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | KRT18, KMO, H1-5 | KDM4E 289/4885HSD17B10 222/4885ALDH1A1 780/4885 |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | KRT18, KMO, H1-5 | KDM4E 289/4885HSD17B10 222/4885ALDH1A1 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.