Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | POLA1 | P09884 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 8/20 | 0.50 |
| ▸ | F2 | P00734 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5001987 | 0.86 | ALDH1A1 (0.53) | RXFP1THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL7943338 | 0.82 | RXFP1 (0.59) | RXFP1THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL5001815 | 0.81 | RXFP1 (0.61) | RXFP1THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL13838674 | 0.81 | RXFP1 (1.00) | RXFP1THRBMEN1KMT2AALDH1A1 | |
| SCHEMBL5008054 | 0.78 | KDM4E (0.47) | RXFP1MEN1KMT2AALDH1A1F10 | |
| SCHEMBL5981594 | 0.77 | MAPT (0.58) | RXFP1MEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL5007922 | 0.75 | L3MBTL1 (0.59) | RXFP1MEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL4998210 | 0.74 | L3MBTL1 (0.55) | RXFP1ALDH1A1NPSR1TP53LMNA | |
| SCHEMBL2928038 | 0.74 | KDM4E (0.47) | RXFP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL5002229 | 0.73 | F10 (0.43) | RXFP1THRBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7064143-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2006-06-20 | — | — | US | claimed |
| US-20050245595-A1 | Positive modulators of nicotinic receptor agonists | GURLEY DAVID | 2005-11-03 | — | — | US | claimed |
| EP-1230218-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | claimed |
| WO-2001032622-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | claimed |
| US-7402604-B2 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2008-07-22 | — | — | US | disclosed |
| US-7064143-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2006-06-20 | — | — | US | disclosed |
| US-20050245595-A1 | Positive modulators of nicotinic receptor agonists | GURLEY DAVID | 2005-11-03 | — | — | US | disclosed |
| EP-1230218-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032622-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245595-A1 | Positive modulators of nicotinic receptor agonists | CHRM1, CHRM2, CHRNA1 | RXFP1 107/4885THRB 167/4885MEN1 3018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.