Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4998210 | 0.97 | L3MBTL1 (0.55) | L3MBTL1MAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL5981594 | 0.93 | MAPT (0.58) | L3MBTL1MAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL2928038 | 0.82 | KDM4E (0.47) | L3MBTL1MAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL5008054 | 0.82 | KDM4E (0.47) | MAPTHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL5002223 | 0.79 | F10 (0.43) | L3MBTL1MAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL5132653 | 0.76 | MAPT (0.53) | MAPTHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL2929583 | 0.76 | HSD17B10 (0.42) | L3MBTL1MAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL5985923 | 0.76 | KMT2A (0.62) | L3MBTL1MEN1KMT2A | |
| SCHEMBL4998178 | 0.75 | RXFP1 (0.67) | ALDH1A1NPSR1TP53RXFP1LMNA | |
| SCHEMBL5005302 | 0.75 | MLYCD (0.43) | HPGDALDH1A1HSD17B10TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7064143-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2006-06-20 | — | — | US | claimed |
| US-20050245595-A1 | Positive modulators of nicotinic receptor agonists | GURLEY DAVID | 2005-11-03 | — | — | US | claimed |
| EP-1230218-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | claimed |
| WO-2001032622-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | claimed |
| US-7402604-B2 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2008-07-22 | — | — | US | disclosed |
| US-7064143-B1 | Positive modulators of nicotinic receptor agonists | ASTRAZENECA AB (SE) | 2006-06-20 | — | — | US | disclosed |
| US-20050245595-A1 | Positive modulators of nicotinic receptor agonists | GURLEY DAVID | 2005-11-03 | — | — | US | disclosed |
| EP-1230218-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032622-A1 | POSITIVE MODULATORS OF NICOTINIC RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245595-A1 | Positive modulators of nicotinic receptor agonists | CHRM1, CHRM2, CHRNA1 | L3MBTL1 3369/4885MAPT 1941/4885HPGD 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.