Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.76 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.76 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.76 |
| ▸ | PDE1A | P54750 | 4/20 | 0.63 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.63 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.63 |
| ▸ | PDE2A | O00408 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.63 |
| ▸ | PDE6D | O43924 | 1/20 | 0.63 |
| ▸ | PDE8A | O60658 | 1/20 | 0.63 |
| ▸ | PDE9A | O76083 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | PDE6A | P16499 | 1/20 | 0.63 |
| ▸ | PDE6G | P18545 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 1/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30199894 | 0.93 | PDE5A (0.75) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL18416781 | 0.92 | PDE5A (0.78) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30199978 | 0.91 | PDE5A (0.74) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6713790 | 0.89 | PDE5A (0.85) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL16558010 | 0.88 | PDE5A (0.70) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL1058 | 0.86 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL31202790 | 0.86 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30917340 | 0.86 | KMT2A (0.59) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30848723 | 0.86 | PDE5A (0.67) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL19254528 | 0.85 | PDE5A (0.78) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118878542-A | Haomaxidenafil derivative and synthesis method and application thereof | 西安市食品药品检验所 | 2024-11-01 | — | — | CN | disclosed |
| CN-117969703-A | Method for detecting content of thionafil derivative in food or Chinese patent medicine | 上海市食品药品检验研究院 | 2024-05-03 | — | — | CN | disclosed |