Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.78 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.78 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.78 |
| ▸ | PDE1A | P54750 | 4/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.65 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.65 |
| ▸ | PDE2A | O00408 | 1/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.65 |
| ▸ | PDE6D | O43924 | 1/20 | 0.65 |
| ▸ | PDE8A | O60658 | 1/20 | 0.65 |
| ▸ | PDE9A | O76083 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | PDE6A | P16499 | 1/20 | 0.65 |
| ▸ | PDE6G | P18545 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19254528 | 0.93 | PDE5A (0.78) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL16558010 | 0.93 | PDE5A (0.70) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL29282029 | 0.92 | PDE5A (0.76) | PDE5APDE3BPDE3APDE1APDE1B | |
| Sildenafil SCHEMBL492566 | 0.91 | PDE5A (0.77) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil Carbonate SCHEMBL18074278 | 0.91 | PDE5A (0.66) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL19518061 | 0.89 | PDE5A (0.77) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL2033330 | 0.89 | PDE5A (0.66) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL1058 | 0.88 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| Lodenafil SCHEMBL31202790 | 0.88 | PDE5A (1.00) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL14946624 | 0.87 | PDE5A (0.65) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210322413-A1 | NITRIC OXIDE RELEASING PHOSPHODIESTERASE TYPE 5 INHIBITOR | NICOX S.A. (FR) | 2021-10-21 | — | — | US | disclosed |
| US-20190008870-A1 | COMPOSITIONS AND METHODS FOR LIPID METABOLISM DISORDER | JANSFAT BIOTECHNOLOGY CO LTD (TW) | 2019-01-10 | — | — | US | disclosed |
| US-9833456-B2 | Treatment of erectile dysfunction and other indications | STRATEGIC SCIENCE & TECHNOLOGIES, LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9833456-B2 | Treatment of erectile dysfunction and other indications | STRATEGIC SCIENCE & TECHNOLOGIES, LLC (US) | 2017-12-05 | — | — | US | disclosed |
| EP-3241552-A1 | COMPOSITIONS AND METHODS FOR LIPID METABOLISM DISORDER | Jansfat Biotechnology Co., Ltd. (TW) | 2017-11-08 | — | — | EP | disclosed |
| US-20170312286-A1 | COMPOSITIONS AND METHODS FOR LIPID METABOLISM DISORDER | JANSFAT BIOTECHNOLOGY CO., LTD. (TW) | 2017-11-02 | — | — | US | disclosed |
| US-20170027942-A1 | TREATMENT OF ERECTILE DYSFUNCTION AND OTHER INDICATIONS | STRATEGIC SCIENCE & TECHNOLOGIES, LLC (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170027942-A1 | TREATMENT OF ERECTILE DYSFUNCTION AND OTHER INDICATIONS | STRATEGIC SCIENCE & TECHNOLOGIES, LLC (US) | 2017-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170312286-A1 | COMPOSITIONS AND METHODS FOR LIPID METABOLISM DISORDER | GYS2, PYGL, GYS1 | PDE5A 14/4885PDE3B 78/4885PDE3A 69/4885 |
| US-20210322413-A1 | NITRIC OXIDE RELEASING PHOSPHODIESTERASE TYPE 5 INHIBITOR | PDE5A, PDE6A, PDE3A | PDE5A 1/4885PDE3B 6/4885PDE3A 3/4885 |
| US-20190008870-A1 | COMPOSITIONS AND METHODS FOR LIPID METABOLISM DISORDER | GYS2, PYGL, GYS1 | PDE5A 14/4885PDE3B 78/4885PDE3A 69/4885 |
| US-20170027942-A1 | TREATMENT OF ERECTILE DYSFUNCTION AND OTHER INDICATIONS | PDE5A, PDE3A, PDE12 | PDE5A 1/4885PDE3B 5/4885PDE3A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.