Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 4/20 | 0.46 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930504 | 0.93 | FAAH (0.45) | GPR6FAAHALDH1A1KDM4EMEN1 | |
| SCHEMBL2931360 | 0.92 | GPR6 (0.47) | GPR6FAAHACHE | |
| SCHEMBL2925605 | 0.89 | FAAH (0.40) | GPR6FAAHACHEALDH1A1LPAR2 | |
| SCHEMBL1760954 | 0.89 | FAAH (0.49) | GPR6FAAHALDH1A1KDM4EMEN1 | |
| SCHEMBL2931169 | 0.88 | OGA (0.38) | GPR6FAAHACHELPAR2MEN1 | |
| SCHEMBL3049811 | 0.87 | MEN1 (0.42) | FAAHACHEALDH1A1LPAR2MEN1 | |
| SCHEMBL2929411 | 0.87 | ADORA2A (0.41) | ACHEALDH1A1KDM4EMEN1HTT | |
| SCHEMBL2927982 | 0.87 | ADORA2B (0.47) | FAAHALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2930506 | 0.86 | GPR6 (0.38) | GPR6ACHEALDH1A1MEN1KMT2A | |
| SCHEMBL2931204 | 0.85 | GPR6 (0.47) | GPR6FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |