Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CHKA | P35790 | 5/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12658239 | 0.85 | LMNA (0.56) | LMNAALDH1A1MC4RKDM4EMAPT | |
| SCHEMBL2927003 | 0.82 | LMNA (0.53) | LMNAALDH1A1MC4RKDM4EMAPT | |
| SCHEMBL1394191 | 0.79 | LMNA (0.53) | LMNAALDH1A1MC4RKDM4EMAPT | |
| SCHEMBL2934367 | 0.79 | LMNA (0.53) | LMNAALDH1A1MC4RKDM4EMAPT | |
| SCHEMBL2930022 | 0.78 | KDM4E (0.49) | LMNAALDH1A1MC4RKDM4ECHKA | |
| SCHEMBL15495062 | 0.77 | CHKA (0.58) | LMNAALDH1A1MC4RKDM4EMAPT | |
| SCHEMBL2477654 | 0.75 | LMNA (0.67) | LMNAALDH1A1MC4RKDM4EMAPT | |
| SCHEMBL4427871 | 0.75 | LMNA (0.67) | LMNAALDH1A1MC4RKDM4ECHKA | |
| SCHEMBL9996727 | 0.75 | KDM4E (0.64) | LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL2933199 | 0.75 | CRHBP (0.50) | LMNAALDH1A1MC4RKDM4ECHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |