Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CHKA | P35790 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930022 | 0.88 | KDM4E (0.49) | CRHBPCRHR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL520005 | 0.82 | LMNA (0.57) | CRHBPCRHR2SMN1; SMN2CHKAHTT | |
| SCHEMBL13559777 | 0.82 | CHKA (0.56) | CRHBPCRHR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29952833 | 0.81 | KMT2A (0.50) | CRHBPCRHR2SMN1; SMN2KDM4ECHKA | |
| SCHEMBL1911878 | 0.80 | CRHBP (0.55) | CRHBPCRHR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2934367 | 0.80 | LMNA (0.53) | KDM4EALDH1A1CHKALMNAMC4R | |
| SCHEMBL9996727 | 0.79 | KDM4E (0.64) | KDM4EALDH1A1TSHRHTTLMNA | |
| SCHEMBL21565559 | 0.79 | KMT2A (0.50) | CRHBPCRHR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL21550472 | 0.79 | HTT (0.56) | ALDH1A1CHKAHTTLMNATGFBR1 | |
| SCHEMBL29959053 | 0.79 | LMNA (0.57) | CRHBPCRHR2SMN1; SMN2ALDH1A1CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |