Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | FGR | P09769 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934362 | 0.91 | CHEK1 (0.58) | CHEK1PARP1KCNH2JAK2JAK3 | |
| SCHEMBL2931062 | 0.88 | CHEK1 (0.59) | CHEK1PARP1KCNH2JAK2JAK3 | |
| SCHEMBL1928891 | 0.85 | CHEK1 (0.66) | CHEK1PARP1KCNH2JAK2JAK3 | |
| SCHEMBL2933735 | 0.83 | CHEK1 (0.44) | CHEK1DDR1KCNH2JAK2JAK3 | |
| SCHEMBL2928252 | 0.83 | CHEK1 (0.42) | CHEK1KCNH2JAK2JAK3IKBKB | |
| SCHEMBL5243288 | 0.82 | CHEK1 (0.41) | CHEK1KCNH2JAK2JAK3FAAH | |
| SCHEMBL2925535 | 0.82 | JAK2 (0.43) | CHEK1LYNEPHA3KCNH2ABL1 | |
| SCHEMBL2930060 | 0.82 | CHEK1 (0.70) | CHEK1JAK2IKBKBALDH1A1 | |
| SCHEMBL2933445 | 0.81 | CHEK1 (0.72) | CHEK1IKBKBALDH1A1 | |
| SCHEMBL2932975 | 0.79 | PTGER1 (0.43) | CHEK1KCNH2JAK2JAK3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |