Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 7/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29293271 | 0.74 | KCNH2 (0.36) | DRD3 | |
| SCHEMBL29293219 | 0.73 | TAAR1 (0.49) | — | |
| SCHEMBL29293276 | 0.62 | TAAR1 (0.49) | — | |
| SCHEMBL8146287 | 0.62 | HTR2A (0.43) | — | |
| SCHEMBL29293319 | 0.62 | CRHR1 (0.36) | CRHR1NOS3NOS1NOS2 | |
| SCHEMBL29293547 | 0.61 | MAOA (0.43) | — | |
| SCHEMBL10324879 | 0.61 | CYP1A2 (0.50) | DRD2DRD3BCHEACHE | |
| SCHEMBL10041305 | 0.61 | DRD2 (0.47) | DRD2DRD3BCHEACHE | |
| SCHEMBL8160113 | 0.60 | HTR2A (0.41) | — | |
| SCHEMBL20404054 | 0.60 | DRD2 (0.47) | DRD2DRD3BCHECRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |