Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927231 | 0.80 | KMT2A (0.42) | KMT2AMEN1PTPRBALDH1A1RECQL | |
| SCHEMBL1111262 | 0.79 | PTPRB (0.39) | KMT2AMEN1PTPRBALDH1A1RECQL | |
| SCHEMBL2923423 | 0.79 | MEN1 (0.40) | KMT2AMEN1ALDH1A1RECQLATM | |
| SCHEMBL2923426 | 0.74 | CTSK (0.42) | KMT2AMEN1ALDH1A1ATMSYK | |
| SCHEMBL2929227 | 0.74 | CTSK (0.42) | KMT2AMEN1ALDH1A1ATMSYK | |
| SCHEMBL2490507 | 0.69 | ABCB11 (0.49) | KMT2APTPRBALDH1A1RECQLKDM4E | |
| SCHEMBL7233451 | 0.69 | PTPRB (0.45) | PTPRBALDH1A1RECQLSYKKDM4E | |
| SCHEMBL2925457 | 0.69 | PTPRB (0.42) | KMT2AMEN1PTPRBALDH1A1RECQL | |
| SCHEMBL2927031 | 0.69 | CTSK (0.45) | KMT2AMEN1ATMSYK | |
| SCHEMBL2923417 | 0.69 | CTSK (0.45) | KMT2AMEN1ATMSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225253-A1 | PHOSPHONIC ACID DERIVATES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009069100-A1 | PHOSPHONIC ACID DERIVATES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-04 | — | — | WO | disclosed |