Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FCER2 | P06734 | 13/20 | 0.64 |
| ▸ | MMP1 | P03956 | 11/20 | 0.64 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.64 |
| ▸ | MMP9 | P14780 | 5/20 | 0.58 |
| ▸ | MMP2 | P08253 | 5/20 | 0.58 |
| ▸ | MMP3 | P08254 | 3/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 2/20 | 0.50 |
| ▸ | MMP14 | P50281 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924219 | 0.89 | MMP1 (0.57) | FCER2MMP1ADAM17MMP9MMP2 | |
| SCHEMBL2930388 | 0.84 | MMP1 (0.58) | FCER2MMP1ADAM17MMP9MMP2 | |
| SCHEMBL13274326 | 0.78 | FCER2 (1.00) | FCER2MMP1ADAM17MMP9MMP2 | |
| SCHEMBL6838720 | 0.78 | FCER2 (1.00) | FCER2MMP1ADAM17MMP9MMP2 | |
| SCHEMBL2927885 | 0.77 | FCER2 (0.71) | FCER2MMP1ADAM17MMP9MMP2 | |
| SCHEMBL7308337 | 0.70 | MMP9 (0.55) | FCER2MMP1ADAM17MMP9MMP2 | |
| SCHEMBL6850869 | 0.68 | MMP1 (1.00) | MMP1ADAM17MMP9MMP2MMP3 | |
| SCHEMBL29368148 | 0.68 | MMP1 (1.00) | MMP1ADAM17MMP9MMP2MMP3 | |
| SCHEMBL3498576 | 0.68 | FCER2 (0.81) | FCER2MMP1ADAM17MMP9MMP2 | |
| SCHEMBL18435374 | 0.68 | NPC1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1234875-B1 | NOVEL METALLOPROTEASE HAVING AGGRECANASE ACTIVITY | ASTELLAS PHARMA INC (JP) | 2010-01-27 | — | — | EP | disclosed |
| US-20040142445-A1 | Novel metalloprotease having aggrecanase activity | YAMANOUCHI PHARMACEUTICAL CO., LTD. | 2004-07-22 | — | — | US | disclosed |
| US-6716613-B1 | JOINT DISEASES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| EP-1234875-A1 | NOVEL METALLOPROTEASE HAVING AGGRECANASE ACTIVITY | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-08-28 | — | — | EP | disclosed |