Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.58 |
| ▸ | MMP3 | P08254 | 6/20 | 0.58 |
| ▸ | MMP9 | P14780 | 4/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.58 |
| ▸ | FCER2 | P06734 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 5/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924219 | 0.89 | MMP1 (0.57) | MMP1MMP3MMP9ADAM17FCER2 | |
| SCHEMBL2927885 | 0.87 | FCER2 (0.71) | MMP1MMP3MMP9ADAM17FCER2 | |
| SCHEMBL2929780 | 0.84 | FCER2 (0.64) | MMP1MMP3MMP9ADAM17FCER2 | |
| SCHEMBL29368148 | 0.73 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL6850869 | 0.73 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL10451735 | 0.70 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL7431945 | 0.70 | LDHA (0.56) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL7431950 | 0.70 | LDHA (0.56) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL10451722 | 0.69 | MMP1 (0.83) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL19200609 | 0.69 | MMP1 (0.51) | MMP1MMP3MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1234875-B1 | NOVEL METALLOPROTEASE HAVING AGGRECANASE ACTIVITY | ASTELLAS PHARMA INC (JP) | 2010-01-27 | — | — | EP | disclosed |
| US-20040142445-A1 | Novel metalloprotease having aggrecanase activity | YAMANOUCHI PHARMACEUTICAL CO., LTD. | 2004-07-22 | — | — | US | disclosed |
| US-6716613-B1 | JOINT DISEASES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| EP-1234875-A1 | NOVEL METALLOPROTEASE HAVING AGGRECANASE ACTIVITY | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-08-28 | — | — | EP | disclosed |