Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446753 | 0.94 | HCRTR1 (0.42) | KDM4EGAAHCRTR1HCRTR2PAX8 | |
| SCHEMBL2931139 | 0.89 | HCRTR1 (0.39) | HCRTR1HCRTR2PAX8ABL1EGFR | |
| SCHEMBL2931530 | 0.89 | HCRTR1 (0.46) | HCRTR1HCRTR2PAX8ABL1EGFR | |
| SCHEMBL2444050 | 0.89 | HCRTR1 (0.47) | KDM4EGAAHCRTR1HCRTR2PAX8 | |
| SCHEMBL2931080 | 0.89 | HCRTR1 (0.42) | GAAHCRTR1HCRTR2CDK4CCND1 | |
| SCHEMBL2933639 | 0.87 | PAX8 (0.39) | KDM4EPAX8ABL1EGFRSRC | |
| SCHEMBL2926961 | 0.87 | MEN1 (0.43) | HCRTR1HCRTR2CDK4CCND1L3MBTL1 | |
| SCHEMBL3414068 | 0.87 | MEN1 (0.43) | HCRTR1HCRTR2CDK4CCND1L3MBTL1 | |
| SCHEMBL2930541 | 0.85 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3415643 | 0.85 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | claimed |
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |