Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 9/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.40 |
| ▸ | PIM1 | P11309 | 5/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 2/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931139 | 0.89 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL2924875 | 0.87 | HCRTR2 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL2929132 | 0.87 | HCRTR1 (0.42) | HCRTR1HCRTR2PIM1PIM2MMP2 | |
| SCHEMBL2933414 | 0.86 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL2925423 | 0.86 | CFD (0.40) | HCRTR1HCRTR2PIM1PIM2MMP2 | |
| SCHEMBL2925064 | 0.85 | HCRTR2 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2929505 | 0.85 | HCRTR2 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2926155 | 0.84 | HDAC7 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2930272 | 0.83 | CHRM1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL2925883 | 0.82 | CHRM1 (0.33) | HCRTR1HCRTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |