Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12274530 | 0.85 | TNK2 (0.33) | LIPETNK2 | |
| SCHEMBL2928213 | 0.72 | PDGFRA (0.44) | EGFRBTKPDGFRAKDR | |
| SCHEMBL13603220 | 0.72 | NOS3 (0.47) | PDGFRAKDRNOS3NOS2SCN9A | |
| SCHEMBL1146056 | 0.71 | ADORA2A (0.42) | EGFRBTKNOS3NOS2TNK2 | |
| SCHEMBL2931209 | 0.69 | BRAF (0.44) | EGFRBTKPDGFRAKDR | |
| SCHEMBL2935339 | 0.68 | PDGFRB (0.34) | EGFRBTKPDGFRAKDR | |
| SCHEMBL3757588 | 0.67 | MAP4K4 (0.47) | PDGFRAKDR | |
| SCHEMBL2926569 | 0.64 | KDR (0.47) | PDGFRAKDR | |
| SCHEMBL2935480 | 0.64 | NPSR1 (0.50) | — | |
| SCHEMBL3759308 | 0.64 | AURKA (0.35) | EGFRBTKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |