Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11824740 | 0.79 | ALDH1A1 (0.44) | RAB9AALDH1A1ADORA2AMAPT | |
| SCHEMBL20506939 | 0.77 | TNF (0.37) | CRHR1TNFMEN1KMT2ARAB9A | |
| SCHEMBL27250319 | 0.75 | PTGS2 (0.40) | CRHR1TNFMEN1KMT2AALDH1A1 | |
| SCHEMBL29311478 | 0.70 | DRD1 (0.33) | TNFMEN1KMT2AALDH1A1HTT | |
| SCHEMBL2645983 | 0.69 | KDM4E (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10308970 | 0.69 | PKM (0.49) | ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL15368193 | 0.69 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL26817055 | 0.68 | MAPT (0.54) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL10308822 | 0.68 | FAAH (0.38) | KMT2AALDH1A1KDM4EMAPK1TSHR | |
| SCHEMBL1441164 | 0.67 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228469-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228469-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | PCSK9, PCSK7, PCSK6 | CRHR1 1509/4885TNF 1724/4885MEN1 258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.