Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 6/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 5/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31009145 | 1.00 | POLQ (0.44) | POLQSCN8ASCN10ACRHR1LIPE | |
| SCHEMBL31009165 | 0.94 | POLQ (0.46) | POLQSCN8ASCN10ACRHR1CMA1 | |
| SCHEMBL29313852 | 0.90 | POLQ (0.41) | POLQSCN8ASCN10ALIPEKMT2A | |
| SCHEMBL29315725 | 0.84 | POLQ (0.38) | POLQSCN8ASCN10AFFAR4 | |
| SCHEMBL31009155 | 0.84 | POLQ (0.38) | POLQSCN8ASCN10AFFAR4 | |
| SCHEMBL29313609 | 0.81 | POLQ (0.40) | POLQLIPECMA1FFAR4 | |
| SCHEMBL30847728 | 0.80 | POLQ (0.42) | POLQLIPECMA1 | |
| SCHEMBL29314473 | 0.79 | POLQ (0.39) | POLQLIPECMA1KMT2AMEN1 | |
| SCHEMBL30847572 | 0.79 | POLQ (0.39) | POLQLIPECMA1KMT2AMEN1 | |
| SCHEMBL31009194 | 0.79 | POLQ (0.44) | POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |