Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.44 |
| ▸ | RXRG | P48443 | 8/20 | 0.44 |
| ▸ | RXRB | P28702 | 7/20 | 0.44 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.42 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29315906 | 0.81 | NOTUM (0.47) | RXRARXRGRXRBCES2LMNA | |
| SCHEMBL15524368 | 0.75 | AKR1B1 (0.43) | RXRARXRGRXRBLMNAAKR1B1 | |
| SCHEMBL6864341 | 0.74 | CES2 (0.46) | RXRARXRGRXRBGPR17CES2 | |
| SCHEMBL29009799 | 0.73 | RXRA (0.50) | RXRARXRGRXRBGPR17AGBL2 | |
| SCHEMBL2184606 | 0.72 | RXRA (0.54) | RXRARXRGRXRBAGBL2PSEN1 | |
| SCHEMBL2525416 | 0.72 | AKR1B1 (0.52) | RXRARXRGRXRBAGBL2CES2 | |
| SCHEMBL15524659 | 0.71 | RXRA (0.50) | RXRARXRGRXRBAGBL2CES2 | |
| SCHEMBL509209 | 0.70 | RXRA (0.49) | RXRARXRGRXRBAGBL2CES2 | |
| SCHEMBL6096516 | 0.70 | RXRA (0.52) | RXRARXRGRXRBGPR17AGBL2 | |
| SCHEMBL7584232 | 0.69 | RXRA (0.39) | RXRARXRGRXRBGPR17AGBL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |