Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29315902 | 0.81 | RXRA (0.44) | NOTUMLMNAMAPTXBP1NPSR1 | |
| SCHEMBL15524632 | 0.78 | NOTUM (0.43) | NOTUMLMNAMAPTMEN1KMT2A | |
| SCHEMBL23531156 | 0.76 | NOTUM (0.56) | NOTUMLMNAHSP90AB1MEN1KMT2A | |
| SCHEMBL15524663 | 0.75 | CFTR (0.43) | NOTUMAKR1C3LMNAMAPTMEN1 | |
| SCHEMBL29315909 | 0.73 | ROCK2 (0.46) | — | |
| SCHEMBL29823794 | 0.73 | NOTUM (0.36) | NOTUMCACNA1H | |
| SCHEMBL1296063 | 0.73 | HSP90AB1 (0.56) | NOTUMLMNAMAPTHSP90AB1CES2 | |
| SCHEMBL15524132 | 0.72 | PPARG (0.44) | NOTUMAKR1C3LMNAMAPTXBP1 | |
| SCHEMBL14661309 | 0.72 | P2RX7 (0.45) | LMNAMAPTHSP90AB1MEN1KMT2A | |
| SCHEMBL18524127 | 0.72 | NOTUM (0.57) | NOTUMLMNAMAPTHSP90AB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |