Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.39 |
| ▸ | RXRG | P48443 | 9/20 | 0.39 |
| ▸ | RXRB | P28702 | 8/20 | 0.39 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6096516 | 0.72 | RXRA (0.52) | RXRARXRGRXRBGPR17AGBL2 | |
| SCHEMBL8462688 | 0.70 | RXRA (0.43) | RXRARXRGRXRBGPR17AGBL2 | |
| SCHEMBL8464813 | 0.70 | RXRA (0.43) | RXRARXRGRXRBGPR17AGBL2 | |
| SCHEMBL29315902 | 0.69 | RXRA (0.44) | RXRARXRGRXRBGPR17AGBL2 | |
| SCHEMBL5574328 | 0.68 | CES2 (0.53) | RXRARXRGRXRBAGBL2POLQ | |
| SCHEMBL30716953 | 0.68 | POLQ (0.61) | RXRARXRGRXRBPOLQPTGDR2 | |
| SCHEMBL3741058 | 0.68 | POLQ (0.61) | RXRARXRGRXRBPOLQPTGDR2 | |
| SCHEMBL30428330 | 0.67 | RXRA (0.50) | RXRARXRGRXRBAGBL2PTGDR2 | |
| SCHEMBL6864341 | 0.67 | CES2 (0.46) | RXRARXRGRXRBGPR17POLQ | |
| SCHEMBL509209 | 0.66 | RXRA (0.49) | RXRARXRGRXRBAGBL2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002102372-A1 | GEM-DISUBSTITUTED CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 2002-12-27 | — | — | WO | disclosed |