Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931600 | 1.00 | LMNA (0.43) | LMNAMAPTSMN1; SMN2HTTKDR | |
| SCHEMBL2935810 | 0.83 | PRMT1 (0.49) | LMNAMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL9909776 | 0.82 | LMNA (0.61) | LMNAMAPTSMN1; SMN2HTTHPGD | |
| SCHEMBL7228451 | 0.76 | ALDH1A1 (0.46) | LMNAMAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL2937189 | 0.76 | PDGFRA (0.45) | LMNAMAPTSMN1; SMN2KDRMEN1 | |
| SCHEMBL2937186 | 0.76 | PDGFRA (0.45) | LMNAMAPTSMN1; SMN2KDRMEN1 | |
| SCHEMBL9909775 | 0.71 | MAPT (0.42) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3842300 | 0.70 | LMNA (0.48) | LMNAMAPTSMN1; SMN2HTTKDR | |
| SCHEMBL3842301 | 0.70 | LMNA (0.48) | LMNAMAPTSMN1; SMN2HTTKDR | |
| SCHEMBL4464904 | 0.70 | SMN1; SMN2 (0.42) | LMNAMAPTSMN1; SMN2HTTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |