Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | MITF | O75030 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228254 | 0.84 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTHTTKMT2A | |
| SCHEMBL9909776 | 0.79 | LMNA (0.61) | ALDH1A1LMNAMAPTHTTMITF | |
| SCHEMBL2931600 | 0.76 | LMNA (0.43) | ALDH1A1LMNAMAPTHTTMITF | |
| SCHEMBL2931604 | 0.76 | LMNA (0.43) | ALDH1A1LMNAMAPTHTTMITF | |
| SCHEMBL29674727 | 0.73 | NOS2 (0.50) | ALDH1A1LMNAMAPTHTTMITF | |
| SCHEMBL204345 | 0.73 | NOS2 (0.50) | ALDH1A1LMNAMAPTHTTMITF | |
| SCHEMBL7222709 | 0.71 | ALDH1A1 (0.39) | ALDH1A1MAPTHTTKDM4EKMT2A | |
| SCHEMBL2935810 | 0.70 | PRMT1 (0.49) | LMNAMAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL7228448 | 0.68 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTHTTMITF | |
| SCHEMBL11472633 | 0.67 | ALDH1A1 (0.63) | ALDH1A1LMNAMAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583138-B1 | Mediators or antagonists of the effects of histamine, leukotriene and the like; heterocyclic ring condensed benzothiazine compounds; inhibit the activation of the tyrosine kinase of 72 kDa | EISAI CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1057830-A1 | HETEROCYCLE-FUSED BENZOTHIAZINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |