Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29316442 | 0.81 | — | — | |
| SCHEMBL25090277 | 0.75 | OPRM1 (0.36) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL26742235 | 0.74 | GNAO1 (0.38) | SIGMAR1 | |
| SCHEMBL8362610 | 0.72 | OPRM1 (0.34) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL22901352 | 0.72 | OPRL1 (0.37) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL22920409 | 0.71 | OPRL1 (0.38) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL27065392 | 0.71 | OPRL1 (0.38) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL24064826 | 0.71 | SIGMAR1 (0.34) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL29325654 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL16788111 | 0.70 | HRH3 (0.41) | OPRM1OPRL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | BCL2A1, BCL2L1, BCL3 | OPRM1 4583/4885OPRL1 4262/4885SIGMAR1 3279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.