Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.36 |
| ▸ | CTSV | O60911 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27377466 | 0.89 | IDO1 (0.36) | ERCC5FEN1HIF1ASRD5A2PTGER1 | |
| SCHEMBL29326304 | 0.83 | MCL1 (0.43) | FEN1HIF1AMRGPRX4PTGER1CTSV | |
| SCHEMBL29326209 | 0.81 | ALDH1A1 (0.41) | ERCC5FEN1KDM4EALDH1A1ADRA1B | |
| SCHEMBL29326166 | 0.81 | ERCC5 (0.60) | ERCC5FEN1KDM4EALDH1A1LMNA | |
| SCHEMBL29326188 | 0.80 | CYP1A1 (0.53) | ERCC5FEN1KDM4EALDH1A1LMNA | |
| SCHEMBL29326183 | 0.80 | ERCC5 (0.43) | ERCC5FEN1KDM4EALDH1A1LMNA | |
| SCHEMBL29326162 | 0.80 | CYP1A1 (0.53) | ERCC5FEN1KDM4EALDH1A1LMNA | |
| SCHEMBL29326663 | 0.80 | HSD17B10 (0.41) | ERCC5FEN1HIF1AKDM4EALDH1A1 | |
| SCHEMBL29326216 | 0.78 | ERCC5 (0.39) | ERCC5FEN1KDM4EALDH1A1LMNA | |
| SCHEMBL29326219 | 0.78 | ERCC5 (0.42) | ERCC5FEN1DHODHKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | ERCC5 2042/4885FEN1 1012/4885HIF1A 2905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.