Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3746673 | 0.80 | ALDH1A1 (0.56) | TRPV4ALDH1A1TSHRNPSR1USP2 | |
| SCHEMBL1038076 | 0.78 | ALDH1A1 (0.57) | TRPV4ALDH1A1TSHRNPSR1USP2 | |
| SCHEMBL5835370 | 0.78 | TRPV4 (0.52) | TRPV4ALDH1A1TSHRKDM4EGAA | |
| SCHEMBL29709827 | 0.77 | TRPV4 (0.60) | TRPV4ALDH1A1TSHRNPSR1KDM4E | |
| SCHEMBL2496224 | 0.77 | TRPV4 (0.60) | TRPV4ALDH1A1TSHRNPSR1KDM4E | |
| SCHEMBL248149 | 0.76 | NMT1 (0.50) | TRPV4TSHRPKMMEN1KMT2A | |
| SCHEMBL28695163 | 0.76 | ALDH1A1 (0.41) | ALDH1A1TSHRNPSR1USP2TP53 | |
| SCHEMBL2266115 | 0.74 | TRPV4 (0.62) | TRPV4ALDH1A1TSHRNPSR1RAB9A | |
| SCHEMBL7526380 | 0.74 | TRPV4 (0.34) | TRPV4ALDH1A1TSHR | |
| SCHEMBL5835958 | 0.73 | TRPV4 (0.56) | TRPV4ALDH1A1TSHRNPSR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229395-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009090054-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-07-23 | — | — | WO | disclosed |