Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 4/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070878 | 0.91 | KCNA3 (0.39) | HDAC8KCNA3MAPTALDH3A1TDP1 | |
| SCHEMBL20969950 | 0.86 | PRSS1 (0.41) | HDAC8KCNA3MAPTALDH1A1CA12 | |
| SCHEMBL5636691 | 0.83 | KCNA3 (0.46) | KCNA3ALDH1A1L3MBTL1PRSS1 | |
| SCHEMBL38655982 | 0.82 | KCNA3 (0.48) | HDAC8KCNA3L3MBTL1HRH3PRSS1 | |
| SCHEMBL2935432 | 0.79 | FABP7 (0.40) | HDAC8KCNA3CA12CA1CA2 | |
| SCHEMBL1007565 | 0.78 | LTA4H (0.53) | CA12CA1CA2CA9 | |
| SCHEMBL19995157 | 0.78 | APP (0.47) | ALDH1A1CA12CA1CA9APP | |
| SCHEMBL163688 | 0.78 | LTA4H (0.52) | MAPTL3MBTL1CA12CA1CA2 | |
| SCHEMBL7447851 | 0.78 | ALDH1A1 (0.53) | MAPTALDH1A1HRH3MMP2 | |
| SCHEMBL977250 | 0.78 | ALDH1A1 (0.56) | ALDH1A1CA12CA1CA9HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |