Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29330191 | 0.82 | MKNK1 (0.43) | P2RX3MKNK1MAPT | |
| SCHEMBL29329976 | 0.79 | PARP1 (0.42) | MKNK1 | |
| SCHEMBL29330066 | 0.77 | PARP1 (0.39) | MKNK1 | |
| SCHEMBL30603339 | 0.76 | MKNK1 (0.47) | MKNK1 | |
| SCHEMBL29329978 | 0.75 | PDE9A (0.37) | CYP1A2CYP3A4ALOX15TSHRCYP2C19 | |
| SCHEMBL19358203 | 0.74 | TLR9 (0.46) | P2RX3EPHX2MAPTTSHR | |
| SCHEMBL30377840 | 0.72 | MAPT (0.53) | P2RX3EPHX2MAPTMEN1KMT2A | |
| SCHEMBL25574585 | 0.72 | MAPT (0.53) | P2RX3EPHX2MAPTMEN1KMT2A | |
| SCHEMBL21807841 | 0.71 | DNMT3A (0.47) | P2RX3MKNK1MAPTDNMT3ATSHR | |
| SCHEMBL30378278 | 0.71 | P2RX3 (0.51) | P2RX3EPHX2MKNK1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4400500-A1 | HALOGEN-SUBSTITUTED PYRIDAZINONE COMPOUND AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2024-07-17 | — | — | EP | disclosed |