Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29330191 | 0.90 | MKNK1 (0.43) | PARP1TNKS2PARP2MKNK1ESR2 | |
| SCHEMBL29330066 | 0.86 | PARP1 (0.39) | PARP1TNKS2PARP2MKNK1ESR2 | |
| SCHEMBL30603339 | 0.86 | MKNK1 (0.47) | PARP1TNKS2PARP2MKNK1TRPC5 | |
| SCHEMBL21807357 | 0.83 | TRPC5 (0.51) | PARP1TNKS2PARP2MKNK1ESR2 | |
| SCHEMBL29329977 | 0.79 | P2RX3 (0.45) | MKNK1 | |
| SCHEMBL29330275 | 0.78 | MKNK1 (0.48) | MKNK1ESR2TRPC5HPGDSP2RX7 | |
| SCHEMBL21807251 | 0.76 | TRPC5 (0.44) | PARP1TNKS2PARP2ESR2TRPC5 | |
| SCHEMBL21807166 | 0.76 | TRPC5 (0.43) | PARP1TNKS2PARP2MKNK1ESR2 | |
| SCHEMBL30603333 | 0.76 | GPR119 (0.41) | PARP1TNKS2PARP2MKNK1GPR119 | |
| SCHEMBL30603337 | 0.76 | GPR119 (0.41) | PARP1TNKS2PARP2MKNK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4400500-A1 | HALOGEN-SUBSTITUTED PYRIDAZINONE COMPOUND AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2024-07-17 | — | — | EP | disclosed |