Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.66 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.66 |
| ▸ | LTA4H | P09960 | 11/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27995047 | 0.89 | HRH3 (0.60) | CHRNB2CHRNA4HRH3 | |
| SCHEMBL7411609 | 0.80 | CHRNB2 (1.00) | CHRNB2CHRNA4LTA4HPTGS2 | |
| SCHEMBL2935953 | 0.78 | CHRNB2 (0.57) | CHRNB2CHRNA4LTA4HPTGS2PSMB1 | |
| SCHEMBL15884244 | 0.78 | CHRNB2 (0.57) | CHRNB2CHRNA4LTA4HPTGS2PSMB1 | |
| SCHEMBL18474493 | 0.78 | CHRNB2 (0.57) | CHRNB2CHRNA4LTA4HPTGS2PSMB1 | |
| SCHEMBL25578979 | 0.78 | CHRNB2 (0.43) | CHRNB2CHRNA4LTA4HPTGS2PSMB1 | |
| SCHEMBL25059331 | 0.78 | LTA4H (0.87) | CHRNB2CHRNA4LTA4HPTGS2PSMB1 | |
| SCHEMBL2933385 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4LTA4HPTGS2PSMB1 | |
| SCHEMBL18837471 | 0.76 | LTA4H (0.84) | CHRNB2CHRNA4LTA4HPTGS2PSMB1 | |
| SCHEMBL26796103 | 0.76 | KDM4E (0.60) | CHRNB2CHRNA4LTA4HPSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500393-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | claimed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | claimed |