Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1807364 | 0.78 | NAPRT (0.61) | NAPRTMAP2K1KDM4ETDP1SLC6A4 | |
| SCHEMBL21290415 | 0.75 | PDK2 (0.42) | NAPRTMAP2K1KDM4ETDP1SLC6A4 | |
| SCHEMBL29335092 | 0.74 | CYP19A1 (0.38) | NAPRTTDP1TDP2L3MBTL1PKM | |
| SCHEMBL6771957 | 0.73 | LMNA (0.55) | SLC6A4SLC6A3L3MBTL1PKMALDH1A1 | |
| SCHEMBL2929763 | 0.73 | PTGS1 (0.54) | KDM4EL3MBTL1ALDH1A1HPGDPOLB | |
| SCHEMBL29335090 | 0.71 | NAPRT (0.37) | NAPRTKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL4010764 | 0.71 | NR4A2 (0.42) | KDM4EL3MBTL1ALDH1A1POLBCFTR | |
| SCHEMBL4369919 | 0.69 | PTPN1 (0.51) | KDM4ESLC6A4SLC6A3GPBAR1ALDH1A1 | |
| SCHEMBL4022319 | 0.69 | ALDH1A1 (0.52) | KDM4ETDP1L3MBTL1PKMALDH1A1 | |
| SCHEMBL20028523 | 0.68 | JAK2 (0.54) | KDM4ETDP1L3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4649077-A1 | SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF | Cerevel Therapeutics, LLC (US) | 2025-11-19 | — | — | EP | disclosed |
| WO-2024151833-A1 | SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF | CEREVEL THERAPEUTICS, LLC (US) | 2024-07-18 | — | — | WO | disclosed |
| WO-2024151833-A1 | SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF | CEREVEL THERAPEUTICS, LLC (US) | 2024-07-18 | — | — | WO | disclosed |