Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491090 | 0.78 | KCNA5 (0.38) | ALDH1A1L3MBTL1KCNA5 | |
| SCHEMBL2611049 | 0.74 | PARP1 (0.46) | ALDH1A1DRD2DRD4DRD3PARP1 | |
| SCHEMBL27249813 | 0.73 | ALDH1A1 (0.37) | ALDH1A1KCNA5 | |
| SCHEMBL23122595 | 0.73 | DRD2 (0.59) | ATRALDH1A1L3MBTL1AKT1CHEK1 | |
| SCHEMBL7856459 | 0.71 | PARP1 (0.47) | ALDH1A1DRD2DRD4DRD3PARP1 | |
| SCHEMBL24351926 | 0.71 | PARP1 (0.44) | ALDH1A1DRD2DRD4DRD3PARP1 | |
| SCHEMBL7745378 | 0.70 | DPP4 (0.46) | ALDH1A1KCNA5 | |
| SCHEMBL29336243 | 0.69 | HTR1A (0.49) | ALDH1A1L3MBTL1DRD2DRD4DRD3 | |
| SCHEMBL2127998 | 0.69 | PARP1 (0.41) | DRD2DRD4DRD3PARP1 | |
| SCHEMBL18713659 | 0.69 | TSHR (0.42) | ALDH1A1DRD2DRD4DRD3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | NRAS, BRAF, KRAS | ATR 452/4885ALDH1A1 1786/4885L3MBTL1 2913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.