Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1183398 | 0.81 | KMT2A (0.46) | AKR1C3CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL19049057 | 0.80 | SMN1; SMN2 (0.50) | GAAALOX15 | |
| SCHEMBL19049073 | 0.77 | CYP2C9 (0.45) | CYP2C9CYP2C19ALDH1A1DRD4TMEM97 | |
| SCHEMBL25274049 | 0.75 | PPIB (0.57) | CYP2C9CYP2C19ALDH1A1KMT2AMAPK1 | |
| SCHEMBL25274050 | 0.75 | PPIB (0.57) | CYP2C9CYP2C19ALDH1A1KMT2AMAPK1 | |
| SCHEMBL29396441 | 0.75 | PPIB (0.57) | CYP2C9CYP2C19ALDH1A1KMT2AMAPK1 | |
| SCHEMBL3356592 | 0.74 | DRD4 (0.55) | HTR1ADRD2DRD3DRD4CHRNA7 | |
| SCHEMBL11679967 | 0.73 | MTNR1A (0.41) | CYP2C9CYP2C19 | |
| SCHEMBL11680271 | 0.73 | NOTUM (0.43) | MEN1KMT2A | |
| SCHEMBL9015945 | 0.72 | LMNA (0.50) | HTR1AHTR7DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229362-A1 | PIPERAZINES AS ANTI-OBESITY AGENTS | AstraZeneca AB (SE) | 2010-09-22 | — | — | EP | claimed |
| WO-2009071658-A1 | PIPERAZINES AS ANTI-OBESITY AGENTS | BIOVITRUM AB (PUBL) (SE) | 2009-06-11 | — | — | WO | claimed |