SCHEMBL29353093

SCHEMBL29353093

Clc1ccc(N/N=C(\c2ccccc2)c2ccccn2)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 1.00
KDM6B O15054 1/20 1.00
TET3 O43151 1/20 1.00
KDM4A O75164 1/20 1.00
KDM4B O94953 1/20 1.00
KDM5A P29375 1/20 1.00
KDM5C P41229 1/20 1.00
KDM4D Q6B0I6 1/20 1.00
TET2 Q6N021 1/20 1.00
TET1 Q8NFU7 1/20 1.00
KDM4C Q9H3R0 1/20 1.00
KDM5B Q9UGL1 1/20 1.00
KMT2A Q03164 4/20 0.55
GAA P10253 3/20 0.55
MEN1 O00255 3/20 0.55
ALOX12 P18054 2/20 0.55
HPGD P15428 2/20 0.55
AGTR1 P30556 4/20 0.52
RAB9A P51151 5/20 0.51
NPC1 O15118 4/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29382353 1.00 KDM4E (1.00) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL17670545 1.00 KDM4E (1.00) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL17670544 1.00 KDM4E (1.00) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL20214000 1.00 KDM4E (1.00) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL30539398 0.92 KDM4E (0.85) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL4926318 0.84 KDM4E (0.72) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL20101080 0.84 KDM4E (0.72) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL18159120 0.84 KDM4E (0.73) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL31237795 0.81 KDM4E (0.68) KDM4EKDM6BTET3KDM4AKDM4B
SCHEMBL20101021 0.79 KDM4E (0.65) KDM4EKDM6BTET3KDM4AKDM4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025059442-A1 MODULATING PLANT RESPONSES TO STRESS AND GROWTH WITH CHEMICALS REMOTE EPIGENETICS INC. (US) 2025-03-20 WO claimed
US-20240392253-A1 COMPOSITION FOR INDUCTION OF PLURIPOTENT STEM CELL GMU MEDICAL DRUG DEVELOPMENT CO., LTD. (CN) 2024-11-28 US claimed
WO-2024233765-A1 THERAPEUTIC APPROACH TO BLOCK TERMINAL EXHAUSTION OF T CELLS AND SYNERGIZE THE EFFICACY OF T CELL IMMUNOTHERAPIES OHIO STATE INNOVATION FOUNDATION (US) 2024-11-14 WO claimed
US-11873494-B2 Genetic and pharmacological transcriptional upregulation of the repressed FXN gene as a therapeutic strategy for Friedreich ataxia UNIVERSITY OF MASSACHUSETTS (US) 2024-01-16 US claimed
CN-117159542-A Application of JIB-04 in preparing medicine for treating pulmonary alveolar proteinosis 厦门大学 2023-12-05 CN claimed
CN-117088808-A Antifungal compound and application thereof 中国人民解放军海军军医大学 2023-11-21 CN claimed
US-20230285498-A1 TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS CITY OF HOPE 2023-09-14 US claimed
US-20230255951-A1 USE OF JUMONJI C DEMETHYLASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF CHEMOTHERAPY RESISTANCE AND RADIORESISTANCE IN CANCER THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2023-08-17 US claimed
CN-113521291-B Application of ZNF143-MDIG-CDC6 axis in hepatocellular carcinoma 上海市肿瘤研究所 2022-11-29 CN claimed
US-11497740-B2 Use of Jumonji C demethylase inhibitors for the treatment and prevention of chemotherapy resistance and radioresistance in cancer THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-11-15 US claimed
US-11458122-B2 Methods for treating diseases and nerve injuries CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2022-10-04 US claimed
US-20220202792-A1 METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES UNIVERSITY OF HOUSTON SYSTEM (US) 2022-06-30 US claimed
US-20220186183-A1 NOVEL GLIA-LIKE CELLS DIFFERENATIATED FROM SOMATIC CELLS, PREPARATION METHOD THEREFOR, COCKTAIL COMPOSITION FOR PREPARING SAME, CELL THERAPEUTIC AGENT FOR PREVENTING OR TREATING NEUROLOGICAL DISORDERS, COMPRISING SAME, AND METHOD FOR PREVENTING AND TREATING NEUROLOGICAL DISORDERS BY ADMINISTERING SAME Cellapeutics Bio (KR) 2022-06-16 US claimed
US-11311538-B2 Compositions and methods for targeting cancers YALE UNIVERSITY (US) 2022-04-26 US claimed
WO-2022031952-A9 TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS CITY OF HOPE (US) 2022-04-07 WO claimed
EP-3962559-A1 METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES University of Houston System (US) 2022-03-09 EP claimed
WO-2022031952-A2 TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS CITY OF HOPE (US) 2022-02-10 WO claimed
US-20220042023-A1 Genetic and Pharmacological Transcriptional Upregulation of the Repressed FXN Gene as a Therapeutic Strategy for Friedreich Ataxia UNIVERSITY OF MASSACHUSETTS 2022-02-10 US claimed
US-12637453-B2 Pyrazolopyridine inhibitors of c-Jun-n-Terminal kinases and uses thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2026-05-26 US disclosed
CN-113966326-A Water soluble adjuvants 大日本住友制药株式会社 2022-01-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220186183-A1 NOVEL GLIA-LIKE CELLS DIFFERENATIATED FROM SOMATIC CELLS, PREPARATION METHOD THEREFOR, COCKTAIL COMPOSITION FOR PREPARING SAME, CELL THERAPEUTIC AGENT FOR PREVENTING OR TREATING NEUROLOGICAL DISORDERS, COMPRISING SAME, AND METHOD FOR PREVENTING AND TREATING NEUROLOGICAL DISORDERS BY ADMINISTERING SAME GMFG, HGF, BDNF KDM4E 4101/4885KDM6B 3295/4885TET3 4645/4885
US-20220202792-A1 METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES FABP2, MUC1, FABP6 KDM4E 4709/4885KDM6B 3478/4885TET3 2139/4885
US-12637453-B2 Pyrazolopyridine inhibitors of c-Jun-n-Terminal kinases and uses thereof MAP3K1, MAP3K3, MAPK1 KDM4E 4155/4885KDM6B 3099/4885TET3 3841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.