Sugi Predict

Sugi Predict / Compounds / SCHEMBL2935519

SCHEMBL2935519

SCHEMBL2935519

CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)N(C(=O)OC(C)(C)C)C(=O)c1ccc(CF)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 2/20 0.40
▸ HDAC2 Q92769 2/20 0.40
▸ HDAC3 O15379 1/20 0.40
▸ NCOR2 Q9Y618 1/20 0.40
▸ GPR119 Q8TDV5 5/20 0.36
▸ HPGD P15428 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ HDAC6 Q9UBN7 1/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ SLC7A5 Q01650 1/20 0.35
▸ ELANE P08246 1/20 0.34
▸ NR1H4 Q96RI1 2/20 0.34
▸ EPHX2 P34913 1/20 0.34
▸ LPAR1 Q92633 2/20 0.33
▸ LPAR5 Q9H1C0 2/20 0.33
▸ ESRRG P62508 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2937645 0.86 GPR119 (0.47) HDAC1HDAC2HDAC3NCOR2GPR119
SCHEMBL9908273 0.79 HDAC3 (0.41) HDAC1HDAC2HDAC3NCOR2GPR119
SCHEMBL2937142 0.79 HDAC3 (0.37) HDAC1HDAC2HDAC3NCOR2GPR119
SCHEMBL8024736 0.77 CA1 (0.49) HDAC1SMN1; SMN2HDAC6ALDH1A1SLC7A5
SCHEMBL2937753 0.73 HDAC3 (0.42) HDAC1HDAC2HDAC3NCOR2SMN1; SMN2
SCHEMBL28757937 0.72 HDAC1 (0.39) HDAC1HDAC2HDAC3NCOR2HDAC6
SCHEMBL6529111 0.70 GPR119 (0.46) HDAC1HDAC2HDAC3NCOR2GPR119
SCHEMBL22284131 0.68 KMT2A (0.67) HPGDSMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL31725156 0.68 PYCR1 (0.49) HDAC1HDAC2HDAC3NCOR2GPR119
SCHEMBL28989018 0.68 ESRRG (0.52) HDAC1HDAC2HDAC3NCOR2GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8197793-B2 Methods of radiofluorination of biologically active vectors GE HEALTHCARE AS (NO) 2012-06-12 — — US disclosed
US-8197793-B2 Methods of radiofluorination of biologically active vectors GE HEALTHCARE AS (NO) 2012-06-12 — — US disclosed
US-8197793-B2 Methods of radiofluorination of biologically active vectors GE HEALTHCARE AS (NO) 2012-06-12 — — US disclosed
EP-1601384-B1 METHODS OF RADIOFLUORINATION OF BIOLOGICALLY ACTIVE VECTORS GE HEALTHCARE AS (NO) 2010-09-22 — — EP disclosed
EP-1601384-B1 METHODS OF RADIOFLUORINATION OF BIOLOGICALLY ACTIVE VECTORS GE HEALTHCARE AS (NO) 2010-09-22 — — EP disclosed
US-20100068139-A1 Methods of radiofluorination of biologically active vectors GE HEALTHCARE AS (NO) 2010-03-18 — — US disclosed
US-20100068139-A1 Methods of radiofluorination of biologically active vectors GE HEALTHCARE AS (NO) 2010-03-18 — — US disclosed
US-20100068139-A1 Methods of radiofluorination of biologically active vectors GE HEALTHCARE AS (NO) 2010-03-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100068139-A1 Methods of radiofluorination of biologically active vectors DOHH, VGF, HNRNPH3 HDAC1 368/4885HDAC2 1097/4885HDAC3 188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.