Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21144246 | 1.00 | TRPV4 (0.51) | TRPV4 | |
| SCHEMBL21144245 | 1.00 | TRPV4 (0.51) | TRPV4 | |
| SCHEMBL21172225 | 0.84 | TRPV4 (0.49) | TRPV4 | |
| SCHEMBL21144272 | 0.84 | ATM (0.48) | TRPV4 | |
| SCHEMBL21144271 | 0.84 | ATM (0.48) | TRPV4 | |
| SCHEMBL21171930 | 0.83 | TRPV4 (0.48) | TRPV4 | |
| SCHEMBL20003505 | 0.82 | TRPV4 (0.53) | TRPV4 | |
| SCHEMBL30014547 | 0.82 | TRPV4 (0.53) | TRPV4 | |
| SCHEMBL20007287 | 0.75 | TRPV4 (0.55) | TRPV4 | |
| SCHEMBL21144183 | 0.72 | TRPV4 (0.50) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11229623-B2 | TRPV4 antagonists | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2022-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11229623-B2 | TRPV4 antagonists | TRPV4, TRPV5, TRPV2 | TRPV4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.