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Sugi Predict / Compounds / Nogalamycin

Nogalamycin

Nogalamycin

SCHEMBL29356331

COC(=O)[C@@H]1c2cc3c(c(O)c2[C@@H](O[C@@H]2O[C@@H](C)[C@H](OC)[C@@](C)(OC)[C@H]2OC)C[C@]1(C)O)C(=O)c1c(O)cc2c(c1C3=O)O[C@@H]1O[C@@]2(C)[C@H](O)[C@@H](N(C)C)[C@@H]1O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 3/20 0.72
▸ ALDH1A1 P00352 2/20 0.72
▸ CYP1A2 P05177 2/20 0.72
▸ HPGD P15428 2/20 0.72
▸ ALOX15 P16050 2/20 0.72
▸ CYP2D6 P10635 1/20 0.72
▸ MEN1 O00255 3/20 0.45
▸ USP2 O75604 3/20 0.45
▸ MAPT P10636 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ KDM4E B2RXH2 2/20 0.45
▸ THRB P10828 2/20 0.45
▸ BLM P54132 2/20 0.45
▸ CASP1 P29466 1/20 0.45
▸ TP53 P04637 2/20 0.41
▸ CYP3A4 P08684 2/20 0.41
▸ RECQL P46063 2/20 0.41
▸ HBB P68871 2/20 0.41
▸ RGS12 O14924 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nogalamycin SCHEMBL4472 1.00 HSD17B10 (0.72) HSD17B10ALDH1A1CYP1A2HPGDALOX15
Nogalamycin SCHEMBL4473 1.00 HSD17B10 (0.72) HSD17B10ALDH1A1CYP1A2HPGDALOX15
Nogalamycin SCHEMBL1649692 1.00 HSD17B10 (0.72) HSD17B10ALDH1A1CYP1A2HPGDALOX15
Nogalamycinic Acid SCHEMBL30055177 0.95 HSD17B10 (0.65) HSD17B10ALDH1A1CYP1A2HPGDALOX15
SCHEMBL18567081 0.91 HSD17B10 (0.72) HSD17B10ALDH1A1CYP1A2HPGDALOX15
Disnogamycin SCHEMBL29390994 0.88 HSD17B10 (0.55) HSD17B10ALDH1A1CYP1A2HPGDALOX15
Disnogamycin SCHEMBL26459009 0.88 HSD17B10 (0.55) HSD17B10ALDH1A1CYP1A2HPGDALOX15
SCHEMBL3345418 0.84 HSD17B10 (1.00) HSD17B10ALDH1A1CYP1A2HPGDALOX15
SCHEMBL11468050 0.84 HSD17B10 (1.00) HSD17B10ALDH1A1CYP1A2HPGDALOX15
SCHEMBL18593716 0.77 HSD17B10 (0.52) HSD17B10ALDH1A1CYP1A2HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 796 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137806-A1 INTERCALATING SUGAR MOLECULES XALUD THERAPEUTICS, INC. (US) 2026-05-21 — — US claimed
EP-3277381-B1 NITROBENZYL DERIVATIVES OF ANTI-CANCER AGENTS OBI PHARMA INC (TW) 2026-01-07 — — EP claimed
EP-4525855-A1 INTERCALATING SUGAR MOLECULES Xalud Therapeutics, Inc. (US) 2025-03-26 — — EP claimed
EP-4426727-A2 SPECIFIC CONJUGATION OF AN ANTIBODY Hangzhou Dac Biotech Co., Ltd. (CN) 2024-09-11 — — EP claimed
EP-3541414-B1 CONJUGATED BIOLOGICAL MOLECULES, PHARMACEUTICAL COMPOSITIONS AND METHODS OBI PHARMA INC (TW) 2024-08-28 — — EP claimed
EP-3380124-B1 CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO LEGOCHEM BIOSCIENCES INC (KR) 2024-04-03 — — EP claimed
US-20240025969-A1 NPC1 MONOBODIES AND MONOBODY CONJUGATES THEREOF NEW YORK UNIVERSITY 2024-01-25 — — US claimed
US-20240016944-A1 MACROPINOCYTOSIS SELECTIVE MONOBODY-DRUG CONJUGATES NEW YORK UNIVERSITY 2024-01-18 — — US claimed
WO-2023225631-A1 INTERCALATING SUGAR MOLECULES XALUD THERAPEUTICS, INC. (US) 2023-11-23 — — WO claimed
WO-2023212704-A2 MACROPINOCYTOSIS SELECTIVE NON-BINDING PROTEIN-DRUG CONJUGATES TEZCAT BIOSCIENCES, INC. (US) 2023-11-02 — — WO claimed
EP-4243874-A1 MACROPINOCYTOSIS SELECTIVE MONOBODY-DRUG CONJUGATES New York University (US) 2023-09-20 — — EP claimed
EP-3122757-B1 CHARGED LINKERS AND THEIR USES FOR CONJUGATION HANGZHOU DAC BIOTECH CO LTD (CN) 2023-09-06 — — EP claimed
US-20230126139-A1 HETEROCYCLIC INHIBITORS OF RHO GTPases FOR THE TREATMENT OF DISEASE MBQ PHARMA 2023-04-27 — — US claimed
WO-2022078524-A4 SPECIFIC CONJUGATION OF AN ANTIBODY HANGZHOU DAC BIOTECH CO., LTD. (CN) 2022-12-08 — — WO claimed
EP-3641824-B1 HYDROPHILIC LINKERS AND CONJUGATES THEREOF GLYKOS FINLAND OY (FI) 2022-08-31 — — EP claimed
WO-2022103856-A1 MACROPINOCYTOSIS SELECTIVE MONOBODY-DRUG CONJUGATES NEW YORK UNIVERSITY (US) 2022-05-19 — — WO claimed
WO-2022103840-A2 NPC1 MONOBODIES AND MONOBODY CONJUGATES THEREOF NEW YORK UNIVERSITY (US) 2022-05-19 — — WO claimed
WO-2022078524-A2 SPECIFIC CONJUGATION OF AN ANTIBODY HANGZHOU DAC BIOTECH CO., LTD. (CN) 2022-04-21 — — WO claimed
EP-3218007-B1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER INST NAT SANTE RECH MED (FR) 2022-04-06 — — EP claimed
CN-114040779-A Conjugates of cell binding molecules containing branched linkers and cytotoxic agents 杭州多禧生物科技有限公司 2022-02-11 — — CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230126139-A1 HETEROCYCLIC INHIBITORS OF RHO GTPases FOR THE TREATMENT OF DISEASE ARHGDIB, ARHGDIA, ARHGEF1 HSD17B10 2434/4885ALDH1A1 2927/4885CYP1A2 3328/4885
US-20260137806-A1 INTERCALATING SUGAR MOLECULES SLC2A1, SLC2A2, SLC2A4 HSD17B10 653/4885ALDH1A1 542/4885CYP1A2 3814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.