SCHEMBL29356625

SCHEMBL29356625

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O)C(C)C)C(C)C

nearest known ligand 0.71

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ NPY2R P49146 10/20 0.71
▸ NPY1R P25929 10/20 0.71
▸ NPY4R P50391 8/20 0.71
▸ NPY5R Q15761 8/20 0.71
▸ TFPI P10646 4/20 0.66
▸ RAMP3 O60896 3/20 0.62
▸ CALCR P30988 3/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30574249 1.00 NPY2R (0.71) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL30574250 0.97 NPY2R (0.72) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL30574247 0.95 NPY2R (0.74) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL29360416 0.94 NPY2R (0.66) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL4331434 0.90 NPY2R (0.75) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL29359777 0.89 NPY2R (0.63) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL15669203 0.88 NPY2R (0.74) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL15669269 0.88 NPY2R (0.76) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL9979655 0.88 NPY2R (0.69) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL238214 0.87 NPY2R (0.69) NPY2RNPY1RNPY4RNPY5RTFPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117529496-A Small molecule regulated cell signaling expression system 欧特佩斯生物公司 2024-02-06 — — CN claimed
US-20220025003-A1 REAGENTS AND METHODS FOR CONTROLLING PROTEIN FUNCTION AND INTERACTION HOWARD HUGHES MEDICAL INSTITUTE 2022-01-27 — — US claimed
US-20250268938-A1 SMALL MOLECULE-REGULATED CELL SIGNALING EXPRESSION SYSTEM OUTPACE BIO, INC. 2025-08-28 — — US disclosed
US-20250243247-A1 CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION TRUSTEES OF BOSTON UNIVERSITY (US) 2025-07-31 — — US disclosed
US-20250188125-A1 De novo Design of Protein Switches UNIVERSITY OF WASHINGTON 2025-06-12 — — US disclosed
US-12304927-B2 De novo design of protein switches UNIVERSITY OF WASHINGTON (US) 2025-05-20 — — US disclosed
US-12202863-B2 Chimeric antigen receptor (CAR) modulation TRUSTEES OF BOSTON UNIVERSITY (US) 2025-01-21 — — US disclosed
US-12180485-B2 Repressible control of gene expression TRUSTEES OF BOSTON UNIVERSITY (US) 2024-12-31 — — US disclosed
CN-117529496-A Small molecule regulated cell signaling expression system 欧特佩斯生物公司 2024-02-06 — — CN disclosed
US-20230279406-A1 INDUCIBLE CONTROL OF GENE EXPRESSION TRUSTEES OF BOSTON UNIVERSITY (US) 2023-09-07 — — US disclosed
US-20230241026-A1 NOVEL DRUG-CONTROLLED SYSTEMS AND USES THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2023-08-03 — — US disclosed
US-11660288-B2 Drug-controlled systems and uses thereof TRUSTEES OF BOSTON UNIVERSITY (US) 2023-05-30 — — US disclosed
US-20220226485-A1 DE NOVO DESIGN OF PHOSPHORYLATION INDUCIBLE PROTEIN SWITCHES (PHOSPHO-SWITCHES) UNIVERSITY OF WASHINGTON 2022-07-21 — — US disclosed
US-20220218752-A1 LOCKR-MEDIATED RECRUITMENT OF CAR T CELLS FRED HUTCHINSON CANCER CENTER 2022-07-14 — — US disclosed
EP-3983428-A1 DE NOVO DESIGN OF PHOSPHORYLATION INDUCIBLE PROTEIN SWITCHES (PHOSPHO-SWITCHES) University of Washington (US) 2022-04-20 — — EP disclosed
CN-114302895-A Novel design of phosphorylation-induced protein switch (phosphate switch) 华盛顿大学 2022-04-08 — — CN disclosed
US-20220098246-A1 CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION TRUSTEES OF BOSTON UNIVERSITY (US) 2022-03-31 — — US disclosed
US-20220073565-A1 DE NOVO DESIGN OF PROTEIN SWITCHES FOR TUNABLE CONTROL OF PROTEIN DEGRADATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-03-10 — — US disclosed
EP-3947432-A1 CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION Trustees of Boston University (US) 2022-02-09 — — EP disclosed
US-20220025003-A1 REAGENTS AND METHODS FOR CONTROLLING PROTEIN FUNCTION AND INTERACTION HOWARD HUGHES MEDICAL INSTITUTE 2022-01-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11660288-B2 Drug-controlled systems and uses thereof ATF4, MRPL21, SARS1 NPY2R 2590/4885NPY1R 2831/4885NPY4R 2348/4885
US-20230241026-A1 NOVEL DRUG-CONTROLLED SYSTEMS AND USES THEREOF ATF4, MRPL21, TMPRSS2 NPY2R 1912/4885NPY1R 2306/4885NPY4R 1875/4885
US-20250243247-A1 CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION HAVCR2, CPB1, CTRL NPY2R 3151/4885NPY1R 2576/4885NPY4R 3416/4885
US-20220098246-A1 CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION HAVCR2, CPB1, CTRL NPY2R 3151/4885NPY1R 2576/4885NPY4R 3416/4885
US-20220025003-A1 REAGENTS AND METHODS FOR CONTROLLING PROTEIN FUNCTION AND INTERACTION HAVCR2, GTF3C4, GTF3C1 NPY2R 4705/4885NPY1R 4747/4885NPY4R 4318/4885
US-12202863-B2 Chimeric antigen receptor (CAR) modulation HAVCR2, CPB1, CTRL NPY2R 3151/4885NPY1R 2576/4885NPY4R 3416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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