SCHEMBL4331434

SCHEMBL4331434

CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C.CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)CC)[C@@H](C)O)C(C)C

nearest known ligand 0.75

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NPY2R P49146 10/20 0.75
NPY1R P25929 10/20 0.75
NPY4R P50391 8/20 0.75
NPY5R Q15761 8/20 0.75
TFPI P10646 5/20 0.72
VIPR1 P32241 1/20 0.68
RAMP3 O60896 1/20 0.67
CALCR P30988 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15669203 0.97 NPY2R (0.74) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL15669269 0.94 NPY2R (0.76) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL30574247 0.93 NPY2R (0.74) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL4329513 0.93 VIPR1 (0.78) NPY2RNPY1RNPY4RNPY5RVIPR1
SCHEMBL238214 0.91 NPY2R (0.69) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL30574250 0.90 NPY2R (0.72) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL30735721 0.90 NPY2R (0.77) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL29436010 0.90 NPY2R (0.77) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL30433571 0.90 NPY2R (0.69) NPY2RNPY1RNPY4RNPY5RTFPI
SCHEMBL29399759 0.90 NPY2R (0.89) NPY2RNPY1RNPY4RNPY5RTFPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240238382-A1 URI Agonist/Vasodilator LILLY CO ELI (US) 2024-07-18 US disclosed
US-11872266-B2 Rapid-acting insulin compositions ELI LILLY AND COMPANY (US) 2024-01-16 US disclosed
CN-110662551-B Quick acting insulin compositions 伊莱利利公司 2023-07-18 CN disclosed
EP-4169505-A1 RAPID-ACTING INSULIN COMPOSITIONS Eli Lilly and Company (US) 2023-04-26 EP disclosed
EP-4108253-A1 RAPID-ACTING INSULIN COMPOSITIONS Eli Lilly and Company (US) 2022-12-28 EP disclosed
EP-3233108-B1 RAPID-ACTING INSULIN COMPOSITIONS LILLY CO ELI (US) 2022-03-30 EP disclosed
US-20220072105-A1 RAPID-ACTING INSULIN COMPOSITIONS ELI LILLY AND COMPANY 2022-03-10 US disclosed
EP-3943155-A1 RAPID-ACTING INSULIN COMPOSITIONS Eli Lilly and Company (US) 2022-01-26 EP disclosed
US-11207384-B2 Rapid-acting insulin compositions ELI LILLY AND COMPANY (US) 2021-12-28 US disclosed
US-11123406-B2 Rapid-acting insulin compositions ELI LILLY AND COMPANY (US) 2021-09-21 US disclosed
US-20160235693-A1 COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL PHARNEXT (FR) 2016-08-18 US disclosed
WO-2016100042-A1 RAPID-ACTING INSULIN COMPOSITIONS ELI LILLY AND COMPANY (US) 2016-06-23 WO disclosed
US-20160166695-A1 RAPID-ACTING INSULIN COMPOSITIONS ELI LILLY AND COMPANY 2016-06-16 US disclosed
US-20160129087-A1 RAPID-ACTING INSULIN COMPOSITIONS LILLY CO ELI (US) 2016-05-12 US disclosed
WO-2015171484-A1 RAPID-ACTING INSULIN COMPOSITIONS ELI LILLY AND COMPANY (US) 2015-11-12 WO disclosed
WO-2015165948-A2 COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES PHARNEXT (FR) 2015-11-05 WO disclosed
US-20150231123-A1 COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL PHARNEXT (FR) 2015-08-20 US disclosed
EP-2021502-A1 NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY Oy Jurilab Ltd (FI) 2009-02-11 EP disclosed
WO-2007128884-A1 NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY OY JURILAB LTD (FI) 2007-11-15 WO disclosed
US-20050014732-A1 Combination of an aldosterone receptor antagonist and an anti-diabetic agent PHARMACIA CORPORATION (US) 2005-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240238382-A1 URI Agonist/Vasodilator GPR119, INSR, IAPP NPY2R 147/4885NPY1R 85/4885NPY4R 116/4885
US-20160166695-A1 RAPID-ACTING INSULIN COMPOSITIONS INSR, IAPP, GPR119 NPY2R 574/4885NPY1R 253/4885NPY4R 176/4885
US-20160129087-A1 RAPID-ACTING INSULIN COMPOSITIONS INSR, IAPP, GPR119 NPY2R 461/4885NPY1R 183/4885NPY4R 227/4885
US-20050014732-A1 Combination of an aldosterone receptor antagonist and an anti-diabetic agent NR3C2, REN, AGTR1 NPY2R 630/4885NPY1R 861/4885NPY4R 606/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.