Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CHKA | P35790 | 1/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP4 | P49662 | 1/20 | 0.46 |
| ▸ | CASP5 | P51878 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1427630 | 0.86 | GAA (0.54) | GAAGPR183SIGMAR1MEN1KMT2A | |
| SCHEMBL15830266 | 0.83 | CHKA (0.51) | CHKAGPR183SIGMAR1MEN1KMT2A | |
| SCHEMBL16217385 | 0.79 | ALDH1A1 (0.54) | GAACHKASIGMAR1MEN1KMT2A | |
| SCHEMBL18672925 | 0.79 | CHKA (0.48) | CHKASIGMAR1MEN1KMT2ACASP1 | |
| SCHEMBL20097401 | 0.79 | KDM4E (0.49) | GAACHKAALDH1A1KDM4EMAPT | |
| SCHEMBL14791995 | 0.78 | ALDH1A1 (0.47) | GAACHKAGPR183ALDH1A1KDM4E | |
| SCHEMBL2932442 | 0.76 | GPR183 (0.53) | GPR183MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14076364 | 0.76 | SIGMAR1 (0.79) | GAASIGMAR1MEN1KMT2ACASP1 | |
| SCHEMBL6200744 | 0.75 | CHKA (0.50) | CHKASIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL18390558 | 0.75 | CHKA (0.50) | GAACHKASIGMAR1CASP1CASP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |