Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385853 | 0.87 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HTTSLC6A2SLC6A4 | |
| SCHEMBL30493836 | 0.76 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2HTTSLC6A2SLC6A4 | |
| SCHEMBL25330794 | 0.75 | AKR1C3 (0.38) | ALDH1A1SMN1; SMN2LMNATSHRNPSR1 | |
| SCHEMBL4759637 | 0.73 | HTR2A (0.38) | ALDH1A1SLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL7522098 | 0.72 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2HTTSLC6A2SLC6A4 | |
| SCHEMBL15273946 | 0.71 | OPRM1 (0.38) | ALDH1A1SMN1; SMN2HTTSLC6A2SLC6A4 | |
| SCHEMBL25333113 | 0.70 | LIPG (0.39) | — | |
| SCHEMBL5398631 | 0.68 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HTTSLC6A2SLC6A4 | |
| SCHEMBL25330150 | 0.67 | RORC (0.43) | ALDH1A1SMN1; SMN2NPSR1AKR1C3 | |
| SCHEMBL31599514 | 0.67 | KDM4E (0.36) | SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |