Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16121167 | 1.00 | CCR5 (0.43) | CCR5KDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL31728438 | 0.94 | ALDH1A1 (0.40) | CCR5KDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL31728274 | 0.84 | CHRNB2 (0.37) | ALDH1A1MAPK1MAPTTSHRGAA | |
| SCHEMBL30811846 | 0.84 | MAPT (0.37) | ALDH1A1MAPK1MAPTTSHRNPC1 | |
| SCHEMBL20008586 | 0.83 | MAPK1 (0.39) | ALDH1A1MAPK1MAPTTSHRNPC1 | |
| SCHEMBL31728288 | 0.80 | LRRK2 (0.33) | LRRK2 | |
| SCHEMBL30366380 | 0.80 | GAA (0.46) | CCR5KDM4EALDH1A1MAPK1MAPT | |
| SCHEMBL16094963 | 0.80 | CCR5 (0.43) | CCR5KDM4EHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL16094760 | 0.80 | CCR5 (0.43) | CCR5KDM4EALDH1A1MAPK1AKR1C3 | |
| SCHEMBL26087700 | 0.80 | CCR5 (0.43) | CCR5KDM4EHSD17B10ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |