Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18855421 | 0.98 | POLB (0.63) | POLBALDH1A1SMN1; SMN2RAB9AEPHX1 | |
| SCHEMBL11808670 | 0.89 | POLB (0.68) | POLBALDH1A1SMN1; SMN2RAB9AEPHX1 | |
| SCHEMBL668906 | 0.89 | POLB (0.68) | POLBALDH1A1SMN1; SMN2RAB9AEPHX1 | |
| SCHEMBL3400048 | 0.89 | MAPT (0.61) | POLBALDH1A1SMN1; SMN2RAB9AEPHX1 | |
| SCHEMBL11526941 | 0.89 | MAPT (0.61) | POLBALDH1A1SMN1; SMN2RAB9AEPHX1 | |
| SCHEMBL78145 | 0.89 | MAPT (0.61) | POLBALDH1A1SMN1; SMN2RAB9AEPHX1 | |
| Hydrochloric Acid SCHEMBL1919158 | 0.86 | POLB (0.66) | POLBALDH1A1SMN1; SMN2RAB9AEPHX1 | |
| SCHEMBL11526739 | 0.86 | MAPT (0.63) | POLBALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL20677078 | 0.83 | POLB (0.61) | POLBALDH1A1SMN1; SMN2RAB9AEPHX1 | |
| SCHEMBL9934529 | 0.82 | MAPT (0.55) | POLBALDH1A1SMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110313158-A1 | Two Component Recyclable Heterogeneous Catalyst, Process for Preparation Thereof and its Use for Preparation of Amines | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-12-22 | — | — | US | claimed |
| WO-2010097815-A2 | A TWO COMPONENT RECYCLABLE HETEROGENEOUS CATALYST, PROCESS FOR PREPARATION THEREOF AND ITS USE FOR PREPARATION OF AMINES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-09-02 | — | — | WO | claimed |
| CN-103833561-B | The N-arylation method of alkane amine | HENGYANG NORMAL UNIVERSITY (CN) | 2016-01-13 | — | — | CN | disclosed |
| CN-103833561-A | Method for N-arylation of alkane amine | UNIV HENGYANG NORMAL | 2014-06-04 | — | — | CN | disclosed |
| EP-1966225-B1 | TRANSITION METAL COMPLEXES AND PREPARATION METHODS THEREOF | LG CHEMICAL LTD (KR) | 2013-12-25 | — | — | EP | disclosed |
| EP-1966223-B1 | CATALYST COMPOSITION COMPRISING GROUP 4 TRANSITION METAL COMPLEXES AND METHOD FOR PREPARING POLYOLEFINS USING THE SAME | LG CHEMICAL LTD (KR) | 2013-08-14 | — | — | EP | disclosed |
| US-20110313158-A1 | Two Component Recyclable Heterogeneous Catalyst, Process for Preparation Thereof and its Use for Preparation of Amines | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-12-22 | — | — | US | disclosed |
| CN-101402537-B | Uses of 2-pyridine-beta ketone compounds | GUANGZHOU INST BIOMED & HEALTH | 2011-04-27 | — | — | CN | disclosed |
| US-7807762-B2 | Catalyst composition comprising Group 4 transition metal complexes and method for preparing polyolefins using the same | LG CHEM, LTD. (KR) | 2010-10-05 | — | — | US | disclosed |
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| CN-101115715-A | Pyrrolidine derivatives for the treatment of diseases associated with renin activity | NOVARTIS AG (CH) | 2008-01-30 | — | — | CN | disclosed |
| EP-1836163-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | Novartis AG (CH) | 2007-09-26 | — | — | EP | disclosed |
| WO-2007078134-A1 | TRANSITION METAL COMPLEXES AND PREPARATION METHODS THEREOF | LG CHEM. LTD. (KR) | 2007-07-12 | — | — | WO | disclosed |
| WO-2007078133-A1 | CATALYST COMPOSITION COMPRISING GROUP 4 TRANSITION METAL COMPLEXES AND METHOD FOR PREPARING POLYOLEFINS USING THE SAME | LG CHEM. LTD. (KR) | 2007-07-12 | — | — | WO | disclosed |
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | disclosed |
| EP-1651631-A1 | BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE | GENELABS TECHNOLOGIES, INC. (US) | 2006-05-03 | — | — | EP | disclosed |
| US-20050187390-A1 | Bicyclic heteroaryl derivatives | GENELABS TECHNOLOGIES, INC. | 2005-08-25 | — | — | US | disclosed |
| WO-2005012288-A1 | BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE | GENELABS TECHNOLOGIES, INC (US) | 2005-02-10 | — | — | WO | disclosed |
| US-3933908-A | INSECTICIDE | U.S. PHILIPS CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110313158-A1 | Two Component Recyclable Heterogeneous Catalyst, Process for Preparation Thereof and its Use for Preparation of Amines | HCN2, RAC2, HCN1 | POLB 2428/4885ALDH1A1 1225/4885SMN1; SMN2 2016/4885 |
| US-20050187390-A1 | Bicyclic heteroaryl derivatives | HAVCR2, MAVS, ZC3HAV1 | POLB 870/4885ALDH1A1 2299/4885SMN1; SMN2 2019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.