Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25205865 | 1.00 | KMT2A (0.43) | KMT2AMEN1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL25207480 | 0.81 | SMN1; SMN2 (0.46) | KMT2AMEN1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL23931478 | 0.74 | ALDH1A1 (0.56) | KMT2ASMN1; SMN2MAPTRAB9AALOX15 | |
| SCHEMBL10429575 | 0.74 | ALDH1A1 (0.50) | KMT2AMEN1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL8141322 | 0.73 | ALDH1A1 (0.61) | KMT2AMEN1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL11075024 | 0.72 | L3MBTL1 (0.49) | KMT2AMEN1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL10003830 | 0.71 | MAPT (0.43) | KMT2AMAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL30220548 | 0.71 | JMJD6 (0.40) | KMT2AMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL8841223 | 0.70 | KMT2A (0.48) | KMT2AMAPK1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL8687098 | 0.70 | ALDH1A1 (0.51) | KMT2AMEN1SMN1; SMN2MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185293-A1 | COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE | The Regents of The University of Michigan (US) | 2023-05-31 | — | — | EP | disclosed |
| WO-2022020424-A1 | COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-01-27 | — | — | WO | disclosed |